2022 Jun 6;6(6):CD012131. (2007), Topical anesthesia: possible risk factor for endophthalmitis after cataract extraction, Endophthalmitis Study Group, European Society of Cataract & Refractive Surgeons (2007), Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors, Lundstrm M, Wejde G, Stenevi U, Thorburn W, Montan P (2007), Endophthalmitis after cataract surgery: a nationwide prospective study evaluating incidence in relation to incision type and location, Ng JQ, Morlet N, Bulsara MK, Semmens JB (2007), Reducing the risk for endophthalmitis after cataract surgery: population-based nested case-control study: endophthalmitis population study of Western Australia sixth report, Kamalarajah S, Ling R, Silvestri G, Sharma NK, Cole MD, et al. The .gov means its official. Significant increases in acute endophthalmitis risk were seen in all the meta-analyses for without intracameral cefazolin during cataract surgery procedure. Identifying patients at high risk of acute endophthalmitis after cataract surgery is important from both public health and clinical perspectives as this would facilitate detection of disease before the onset of irreversible visual loss enabling earlier intervention. [Survey and reduction of waste production from eye surgery]. Acute Infectious Endophthalmitis After Cataract Surgery Some people may experience secondary cataracts, or posterior capsular opacification, after surgery. The Western Australian Data Linkage System identified all patients who underwent cataract surgery, along with those in whom postoperative endophthalmitis subsequently developed, from 1980 to 2000 inclusive. Please enable it to take advantage of the complete set of features! JAMA Ophthalmol. Intravitreal triple therapy with vancomycin, ceftazidime, and moxifloxacin for bacterial endophthalmitis: A Twelve-year experience. Endophthalmitis Prophylaxis for Cataract Surgery. FOIA Risk factors for postoperative endophthalmitis Ophthalmology. GUID:9A80D7AD-E38A-478E-ADD3-8387F4F3A476. Risk factors for postoperative endophthalmitis - PubMed Our pooled estimates revealed that PCR was associated with an increased risk of more than six-fold for acute endophthalmitis. J Cataract Refract Surg. Would you like email updates of new search results? The impact of contact angle on the biocompatibility of biomaterials, What's the relative risk? According to the innovations in phacoemulsification technology, the types of instruments available to better manage complex cases (pupil stretchers, capsular tension rings, dyes to stain the capsule), increased use of topical anesthesia, improvements in intraocular lenses, changes in preoperative or postoperative medication regimens, and better strategies to deal with intraoperative complications, two more recent studies showed the rates of adverse events, including endophthalmitis, decreased among patients undergoing small-incision phacoemulsification from 1994 to 2006 [22], [67]. HHS Vulnerability Disclosure, Help Am J Ophthalmol. Sahtoe APH, Duraku LS, van der Oest MJW, Hundepool CA, de Kraker M, Bode LGM, Zuidam JM. Many surgeons fear an increased incidence of toxic anterior segment syndrome (TASS) with injected antibiotics, such as the toxic effects of higher concentrations of cefuroxime and vancomycin on human corneal endothelial cells [70]. Although there is hesitation the intracameral injection of antibiotics is increasingly being adopted by physicians, which is likely to grow further with commercial availability of formulations. (2012) Blindness. 2019;137(7) . Unable to load your collection due to an error, Unable to load your delegates due to an error. The .gov means its official. Antiseptics and the Ocular Surface: In Vitro Antimicrobial Activity and Effects on Conjunctival and Corneal Epithelial Cells of a New Liposomal Ocular Spray Containing Biosecur, NCI CPTC Antibody Characterization Program. (2007), Presumed infectious endophthalmitis following cataract surgery in the UK: a case-control study of risk factors, Barry P, Seal DV, Gettinby G, Lees F, Peterson M, et al. The https:// ensures that you are connecting to the HHS Vulnerability Disclosure, Help Kessel L, Flesner P, Andresen J, Erngaard D, Tendal B, Hjortdal J. Acta Ophthalmol. 2012 Aug;38(8):1370-5. doi: 10.1016/j.jcrs.2012.03.024. Simultaneously, there is a rising trend for using intracameral injection of antibiotics at the conclusion of cataract surgery. Consecutive physician billing claims for cataract surgery and specific intraoperative and postoperative procedures related to complications of cataract surgery were identified. and transmitted securely. The European Society of Cataract and Refractive Surgeons (ESCRS) recommends surgeons to instill 5-10% of povidone iodine to the cornea and conjunctival sac for at least 3 . Findings from this analysis suggest that there is a significant association between male gender and acute endophthalmitis. National Physician-Level Endophthalmitis Rates for Cataract Surgery Department of Ophthalmology , No.4 Hospital of Xi'an City, Xi'an, Shanxi Province, People's Republic of China, 3 The whole studies did identify a significant association between silicone intraocular lens and acute endophthalmitis (OR 3.02, 95% CI 2.034.49) (Figure 9). Can cataracts come back after surgery? - Medical News Today Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation. 5 Schmitz S, Dick HB, Krummenauer F, Pfeiffer N. Endophthalmitis in cataract surgery: results of a German study. Possible explanations for the higher complication rates in male patients include behavioral differences (e.g., adherence to postoperative instructions and antibiotic use) [58]; differences in bacterial flora between the genders [59]; and use of a-antagonists, which can increase the surgical complexity, as they can lead to intraoperative floppy iris syndrome [24]. Online ahead of print. (1997), Risk of endophthalmitis after cataract extraction: results from the International Cataract Surgery Outcomes study, Javitt JC, Vitale S, Canner JK, Street DA, Krakauer H, et al. Will intracameral cefuroxime become the new standard in endophthalmitis prevention? Graefes Arch Clin Exp Ophthalmol. The OR for prospective studies was 11.45 (95% CI 5.7222.84), and that from retrospective studies was 9.97 (95% CI 4.6621.33). The https:// ensures that you are connecting to the Reflective consideration of postoperative endophthalmitis as a quality marker. The optimal means to prevent POE remains controversial because conducting the large studies required to investigate an uncommon problem is difficult. (iii) reported a measure of the association either as odds ratio (OR) or relative risk (RR) with 95% confidence interval (CI), or allowed for the calculation of it from the raw data presented in the article, and (iv) the study examined human cases. Preferred cataract surgery practices in Malaysia: a survey based study Overall rates of endophthalmitis were calculated and grouped by patient demographics, surgical facility, season, year, and association with capsular rupture. Endophthalmitis affects the aqueous humor and the vitreous humor. 2022 Oct 23;22(1):410. doi: 10.1186/s12886-022-02633-2. Endophthalmitis remains a devastating complication of cataract surgery, despite improved methods of prophylaxis and surgical technique. Is a clear corneal incision associated with greater odds of endophthalmitis compared with a scleral tunnel or limbal incision? Findings from the meta-analysis show an significant association between extra- or intracapsular cataract extraction and acute endophthalmitis (OR 2.19, 95% CI 1.403.42) compared with phacoemulsification (Figure 4). Objective: Intended to investigate the epidemiological characteristics, risk factors and incidence trend of endophthalmitis after cataract surgery in recent 12 years. Shenoy P, Mehta S, Shah C, Joshi R, Sen P, Patidar N, Kohli GM, Sen A. Indian J Ophthalmol. FOIA Endophthalmitis: controlling infection before and after cataract surgery 2015 Aug;122(8):1625-32. doi: 10.1016/j.ophtha.2015.04.036. Background: To describe the epidemiology, characteristics, risk factors, and outcomes of post-traumatic endophthalmitis. Recent findings. Objective: To identify risk factors for suspected acute endophthalmitis after cataract surgery. In addition, the reference lists from all identified studies were examined. This seems to corroborate experimental studies [55], [68], [69] and also some clinical data, reporting an increased bacterial adhesion to silicone lenses compared with polymethylmethacrylate lOLs and hydrophobic acrylic IOLs, as the first-line implants in most operating practice due to the favoring of foldable IOLs to avoid induction of astigmatism [7476]. The https:// ensures that you are connecting to the Typically, images are focused on the retina in the back of the eye. The bibliographies of the full text articles that were reviewed were searched for relevant references. 2022 Jun;11(3):1067-1077. doi: 10.1007/s40123-022-00492-0. 8600 Rockville Pike Endogenous endophthalmitis is an infection of the eye secondary to sepsis, occurring in 0.04-0.5% of bacteremia or fungemia. Risk factors for acute endophthalmitis following cataract surgery: a official website and that any information you provide is encrypted The OR obtained through analysis of the whole studies was 10.76 (95% CI 6.4517.94) (Figure 6). Patient characteristics were compared. Gondhale H, Jaichandran VV, Jambulingam M, Anand AR, Srinivasan S, Raman R, Sharma T. Indian J Ophthalmol. If the incision is too short, the cataract wound may be susceptible to a postoperative perturbation (such as rubbing of the eye) and wound abnormality. There are potential limitations to the present literature synthesis, some inherent to systematic reviews in general and some particular to our review. Design: Population-based retrospective cohort. Pathophysiology and classification Reflective consideration of postoperative endophthalmitis as a quality marker. The site is secure. National Library of Medicine Inflammation is caused by an infection. Would you like email updates of new search results? Unable to load your collection due to an error, Unable to load your delegates due to an error. J Cataract Refract Surg. government site. Earlier literatures stratified the results over time and noted decreasing endophthalmitis rates, from 0.327% in the 1970s to 0.158% in the 1980s and 0.087% in the 1990s [4], [43], [57]. Stata Tech Bull 1999; STB-47: 157. Kato JM, Tanaka T, de Oliveira LMS, de Oliveira MS, Rossi F, Goldbaum M, Pimentel SLG, de Almeida Junior JN, Yamamoto JH. Accessibility LASIK is the best known and most commonly performed. The incidence of endophthalmitis decreased for extracapsular extraction over the whole period, but not for phacoemulsification over the recent 12 years. Endophthalmitis occurred 4 times more often after combined cases (cataract with other ophthalmic procedures) than after standalone cataract surgeries (0.20% vs. 0.04% of cases), and occurred in 0.35% of patients receiving anterior vitrectomy. Before Even the rate of occurrence is uncertain, with . Acute endophthalmitis was defined using surrogate markers for intraocular infection, including vitrectomy, vitreous injection, or aspiration procedures not in combination with air/fluid exchange or dislocated lens extraction, performed 1 to 14 days after cataract surgery. 2023 Feb 14. doi: 10.1038/s41433-023-02440-z. Patients were defined as having or not having associated endophthalmitis. 2023 Feb 1;6:1017420. doi: 10.3389/fdata.2023.1017420. Arch Ophthalmol. Several risk factors for acute postoperative endophthalmitis (POE) following cataract surgery have been reported but the level of evidence and strength of association is varied. This meta-analysis identified the patient-related and surgery-related factors that affect the risk for acute POE following cataract. The fully adjusted study-specific ORs were combined to estimate the pooled ORs with 95% CI using the random effects model for analyze the heterogeneity. The correction or treatment of these risk factors prior to cataract surgery is desirable to reduce the risk of infection. Disclaimer. Mean 3-month postoperative visual acuity was 20/100 (median, 20/50) among endophthalmitis patients, versus a mean of approximately 20/40 (median, 20/30) among patients without endophthalmitis. The .gov means its official. Department of Ophthalmology, C-MER(Shenzhen)Dennis Lam Eye Hospital, Shenzhen, Guangdong Province, People's Republic of China, 2 Three multicenter prospective randomized partially masked control study concurred that the most pertinent finding of the protective effect against infection produced by the prophylactic use of intracameral cefuroxime (1 mg in 0.1 ml solution) compared with topical disinfection alone [28], [31], [35]. Faculty of Liberal Arts and Social Sciences, The Hong Kong Institute of Education, Hong Kong, People's Republic of China. Sensitivity analysis showed that the Swaddiwudhi pong W study [53] substantially influenced the pooled OR. All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. The overall unadjusted and adjusted rates of suspected acute endophthalmitis were both 1.4 per 1000 cataract surgeries. (2008), Comparison of in vitro safety profiles of vancomycin and cefuroxime on human corneal endothelial cells for intracameral use, Study of experimental intraocular infection, Beyer TL, Vogler G, Sharma D, O'Donnell Jr FE (1984), Protective barrier effect of the posterior lens capsule in exogenous bacterial endophthalmitis an experimental primate study, Beyer TL, O'Donnell FE, Goncalves V, Singh R (1985), Role of the posterior capsule in the prevention of postoperative bacterial endophthalmitis: experimental primate studies and clinical implications, The intraocular lens: challenges in the prevention and therapy of infectious endophthalmitis and posterior capsular opacification, Kodjikian L, Beby F, Rabilloud M, Bruslea D, Halphen I, et al. Conclusions: MeSH The purpose of this study was to critically appraise published reports on and to summarize clinical risk factors associated with acute POE which could be easily assessed by ophthalmologists for the introduction and implementation of preventive measure. 2005 Aug;112(8):1388-94. doi: 10.1016/j.ophtha.2005.02.028. Risk factors for endophthalmitis after cataract surgery: Predictors for causative organisms and visual outcomes - ScienceDirect Journal of Cataract & Refractive Surgery Volume 41, Issue 11, November 2015, Pages 2410-2416 Article Risk factors for endophthalmitis after cataract surgery: Predictors for causative organisms and visual outcomes To identify risk factors for suspected acute endophthalmitis after cataract surgery. A systematic review and meta-analysis of observational studies was performed. Data from four prospective cohort studies [28], [31], [35], [41], one retrospective studies [37] and a pooled estimate from a cross sectional study [20] were used in the meta-analysis. Endogenous Endophthalmitis: yield of the diagnostic evaluation Several studies have reported increased rates of adverse postsurgical events among men [22], [31]. An official website of the United States government. A cataract is the loss of lens transparency due to opacification of the lens. 2021 Jul 27;9(7):e3705. There was no risk-adjusted difference in the incidence rate of endophthalmitis for the various cataract surgery procedure types. However, endophthalmitis is a rare condition that has been controlled by the advent of antibiotics. Risk Factors for Developing Endophthalmitis After Cataract Surgery Epub 2005 Jul 13. Characteristics of Endophthalmitis after Cataract Surgery in the United States Medicare Population. AIM:To identify risk factors associated with post-cataract surgery endophthalmitis (PCE) in type 2 diabetic patients. Intracameral cefuroxime injection at the end of cataract surgery to reduce the incidence of endophthalmitis: French study. Significant nonsurgical risk factors for endophthalmitis after cataract These databases were searched systematically using the terms [(endophthalmitis) and (cataract surgery or cataract extraction or cataract or intracapsular cataract extraction or extracapsular cataract extraction or phacoemulsification) and (risk factors or association)]. Second, the overwhelming number of publications showing retrospective data, and the limited number of prospective and case-controlled studies with appropriate randomization methods, negatively affected the proportion of high-quality articles reviewed.